Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition.

@article{Park2006AlzheimerPP,
  title={Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition.},
  author={James H Park and David A. Gimbel and Tadzia Grandpre and J. Lee and Ji-Eun Kim and Weiwei Aileen Li and Daniel Hong Seng Lee and Stephen M Strittmatter},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 5},
  pages={
          1386-95
        }
}
Pathophysiologic hypotheses for Alzheimer's disease (AD) are centered on the role of the amyloid plaque Abeta peptide and the mechanism of its derivation from the amyloid precursor protein (APP). As part of the disease process, an aberrant axonal sprouting response is known to occur near Abeta deposits. A Nogo to Nogo-66 receptor (NgR) pathway contributes to determining the ability of adult CNS axons to extend after traumatic injuries. Here, we consider the potential role of NgR mechanisms in… CONTINUE READING

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  • 2006
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