Alzheimer pathology of patients carrying apolipoprotein E epsilon 4 allele.

  title={Alzheimer pathology of patients carrying apolipoprotein E epsilon 4 allele.},
  author={Olli Heinonen and Maarit Lehtovirta and Hilkka Soininen and Seppo Helisalmi and Arto J Mannermaa and H Sorvari and O. Kosunen and Leo Palj{\"a}rvi and Markku Ryyn{\"a}nen and Paavo J. Riekkinen},
  journal={Neurobiology of aging},
  volume={16 4},
A recent report suggested that brains of Alzheimer patients homozygous for APOE epsilon 4 show increased amyloid pathology compared to APOE epsilon 3 homozygotes. We studied APOE allele frequencies in 73 AD patients and 38 controls. We also investigated relation of APOE genotypes to beta/A4 immunopositive plaques, cerebrovascular beta/A4 deposition, neurons expressing paired helical filaments (PHFs), and synaptophysin-like immunopositivity in 22 neuropathologically verified AD patients. We also… CONTINUE READING

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