Alzheimer disease without neocortical neurofibrillary tangles

  title={Alzheimer disease without neocortical neurofibrillary tangles},
  author={Pietro Tiraboschi and Marwan N Sabbagh and Lawrence A. Hansen and David P. Salmon and Annette Merdes and Anthony Collins Gamst and Eliezer Masliah and Michael F. Alford and Leon Thal and Jody Corey-Bloom},
  pages={1141 - 1147}
Objective: To compare the clinical and pathologic features of plaque only Alzheimer disease (POAD) with plaque and tangle Alzheimer disease (PTAD). Methods: An autopsy series of 16 patients with POAD and 32 subjects with PTAD on whom extensive antemortem neuropsychological testing was available. Plaques, tangles, and cerebral amyloid angiopathy were examined in the neocortex and hippocampus using thioflavin S staining. In addition, immunocytochemical analysis with AT8 for phosphorylated tau was… 

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