Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles.

@article{Iqbal2014AlzheimerDT,
  title={Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles.},
  author={Khalid Iqbal and Fei Liu and C X Gong},
  journal={Biochemical pharmacology},
  year={2014},
  volume={88 4},
  pages={631-9}
}
The bulk of AD research during the last 25 years has been Aβ-centric based on a strong faith in the Amyloid Cascade Hypothesis which is not supported by the data on humans. To date, Aβ-based therapeutic clinical trials on sporadic cases of AD have been negative. Although most likely the major reason for the failure is that Aβ is not an effective therapeutic target for sporadic AD, initiation of the treatment at mild to moderate stages of the disease is blamed as too late to be effective… CONTINUE READING