Alzheimer disease: mechanistic understanding predicts novel therapies.

  title={Alzheimer disease: mechanistic understanding predicts novel therapies.},
  author={Dennis J Selkoe},
  journal={Annals of internal medicine},
  volume={140 8},
Few diagnoses in medicine are more dispiriting for patients and their families than Alzheimer disease. This insidious dissolution of one’s most human qualities—reasoning, abstraction, language, and memory—now affects upwards of 30 million individuals worldwide. Until recently, the study of Alzheimer disease was fraught with mechanistic ignorance and therapeutic nihilism. But rapid scientific progress in 3 areas, biochemical pathology, genetics, and animal modeling has led to an increasingly… CONTINUE READING