Alzheimer disease: Caspases first

  title={Alzheimer disease: Caspases first},
  author={Jes{\'u}s {\'A}vila},
  journal={Nature Reviews Neurology},
the final effects of alzheimer disease (aD) are evident only when an autopsy is per­ formed. among the features of the patient’s brain found at autopsy, prominent neuronal death and the appearance of two charac­ teristic structures—extracellular senile plaques and intracellular neuro fibril lary tan­ gles (nFts)—are particularly note worthy. the main component of the plaques is the peptide amyloid­β (aβ), whereas nFts are composed of fibrillar poly mers of tau protein. while the presence of… CONTINUE READING
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