Alzheimer-associated mutant ubiquitin impairs spatial reference memory.

  title={Alzheimer-associated mutant ubiquitin impairs spatial reference memory.},
  author={Paula van Tijn and Barbara Hobo and Marian C Verhage and Melly S. Oitzl and Fred van Leeuwen and David F. Fischer},
  journal={Physiology & behavior},
  volume={102 2},
UBB(+1) is a mutant ubiquitin which accumulates in the hallmarks of tauopathies, including Alzheimer's disease. Transgenic mice expressing high levels of neuronal UBB(+1) exhibit moderately decreased proteasome activity and spatial reference memory deficits at 9months of age. In the present study, we characterized the behavioral phenotype of male UBB(+1) transgenic mice at different ages. We show that UBB(+1) transgenic mice displayed an age-related functional decline similar to wild-type… CONTINUE READING