Alzheimer and his disease: a brief history

  title={Alzheimer and his disease: a brief history},
  author={Gabriele Cipriani and Cristina Dolciotti and Lucia Picchi and Ubaldo Bonuccelli},
  journal={Neurological Sciences},
More than 100 years ago, Alois Alzheimer first described the clinical and pathological features of an unusual brain disease during the meeting of the Society of Southwest German Psychiatrists in Tübingen: the patient, Auguste Deter, suffered memory loss, disorientation, hallucinations and delusions and died at the age of 55. In 1910, Emil Kraepelin named the condition with the eponym of “Alzheimer’s disease” (AD) that is, now, the most common neurodegenerative disease with more than 25 million… 
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Over 100 years ago, Alois Alzheimer presented the clinical signs and symptoms of what has been later called "Alzheimer Dementia" in a young woman whose name was Augustine Deter [...].
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History reveals that the distinction between presenile (Alzheimer's disease) and senile dementia was originally based on anecdotal clinical observations and that competition among universities was one of the underlying determinants.
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Between national unification and World War I, Germany was preeminent in many areas of science and medicine, and Alois Alzheimer was one of the founders of the field of neuropathology, which marks this anniversary by discussing his contributions to dementia research.
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The histopathology and APOE genotype of Alois Alzheimer's first patient, Auguste D., marks the beginning of research into Alzheimer disease, and neurofibrillary tangles were first described in this brain.
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Rediscovery of the case described by Alois Alzheimer in 1911: historical, histological and molecular genetic analysis
This case is of historical importance as it may have convinced Kraepelin to name the disease after his co-worker, Alois Alzheimer, and it was shown to be homozygous for apolipoprotein allele ε3 and lacked APP mutations at codons 692, 693, 713 and 717.
Adult dementia: history, biopsy, pathology.
A consideration seems justified that Alzheimer's disease is an age-related, slow virus disease due to a hitherto unknown immune defect and aging as an etiological agent must be clarified before Alzheimer’s disease, in any form, can be considered to be an inevitable consequence of longevity.
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This review traces the evolution of concepts and landmarks in the modern history of Alzheimer's disease and attempts to review the current status of knowledge concerning behavioural, neuropsychological and neuropsychiatric aspects of the disease, emphasizing areas of continuing controversy.
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