Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology.

@article{Schreiber2017AlzheimerDS,
  title={Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology.},
  author={Stefanie Schreiber and Frank Schreiber and Samuel N. Lockhart and Andy Horng and Alexandre Bejanin and Susan M. Landau and William J. Jagust},
  journal={JAMA neurology},
  year={2017},
  volume={74 6},
  pages={650-659}
}
Importance There are conflicting results claiming that Alzheimer disease signature neurodegeneration may be more, less, or similarly advanced in individuals with β-amyloid peptide (Aβ)-negative (Aβ-) suspected non-Alzheimer disease pathophysiology (SNAP) than in Aβ-positive (Aβ+) counterparts. Objective To examine patterns of neurodegeneration in individuals with SNAP compared with their Aβ+ counterparts. Design, Setting, and Participants A longitudinal cohort study was conducted among… CONTINUE READING
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