Alzheimer Abeta(1-42) monomer adsorbed on the self-assembled monolayers.

@article{Wang2010AlzheimerAM,
  title={Alzheimer Abeta(1-42) monomer adsorbed on the self-assembled monolayers.},
  author={Qiuming Wang and Jun Zhao and Xiang Yu and Chao Zhao and Lingyan Li and Jie Zheng},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2010},
  volume={26 15},
  pages={12722-32}
}
Amyloid-beta (Abeta) peptide aggregation on the cell membranes is a key pathological event responsible for neuron cell death in Alzheimer's disease (AD). We present a collection of molecular docking and molecular dynamics simulations to study the conformational dynamics and adsorption behavior of Abeta monomer on the self-assembled monolayer (SAM), in comparison to Abeta structure in bulk solution. Two distinct Abeta conformations (i.e., alpha-helix and beta-hairpin) are selected as initial… CONTINUE READING

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