Alzheimer Abeta(1-42) monomer adsorbed on the self-assembled monolayers.

  title={Alzheimer Abeta(1-42) monomer adsorbed on the self-assembled monolayers.},
  author={Qiuming Wang and Jun Zhao and Xiang Yu and Chao Zhao and Lingyan Li and Jie Zheng},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  volume={26 15},
Amyloid-beta (Abeta) peptide aggregation on the cell membranes is a key pathological event responsible for neuron cell death in Alzheimer's disease (AD). We present a collection of molecular docking and molecular dynamics simulations to study the conformational dynamics and adsorption behavior of Abeta monomer on the self-assembled monolayer (SAM), in comparison to Abeta structure in bulk solution. Two distinct Abeta conformations (i.e., alpha-helix and beta-hairpin) are selected as initial… CONTINUE READING


Publications citing this paper.
Showing 1-8 of 8 extracted citations

The Toxicity of Amyloid β Oligomers

International journal of molecular sciences • 2012
View 2 Excerpts

Similar Papers

Loading similar papers…