• Corpus ID: 67988540

Alzheimer 2003: ¿qué hay de nuevo?

  title={Alzheimer 2003: ¿qu{\'e} hay de nuevo?},
  author={Jos{\'e} Manuel Mart{\'i}nez Lage and L. F. Pascual-Mill{\'a}n},
6 Citations

Cognitive intervention in patients with mild cognitive deterioration and mild dementia

This investigation provides different techniques, tools and methods including therapy, which necessarily contributes to human activity of the medical and paramedical staff in patients with mild cognitive deterioration and mild dementia.


Resumo. Este artigo propoe analisar o perfil social da pessoa portadora da Doenca de Alzheimer (DA). As informacoes foram colhidas junto ao cuidador principal, membro da unidade familiar do idoso e

Consideraciones críticas acerca del programa tradicional de la asignatura Medicina Interna.

The objective of this article was to critically analyze some aspects that can not be omitted if the authors want to foster a subject based in a comprehensive specialty as Internal Medicine.

Plasticidad cognitiva en personas con la enfermedad de Alzheimer que reciben programas de estimulación cognitiva

El objetivo de este estudio es el de investigar potenciales cambios en plasticidad cognitiva tras entrenamientos de psicoestimulacion en enfermos de Alzheimer en fase leve. Participaron en el estudio

Estimación de los costes de los cuidados informales asociados a enfermedades neurológicas de alta prevalencia en España

Se recomienda the realización of una encuesta longitudinal a nivel nacional that permita avanzar en las lagunas that existen sobre las decisiones en el seno familiar asociadas a situaciones de dependencia.



A protein factor essential for microtubule assembly.

The unique ability of tau to restore the normal features of in vitro microtubules assembly makes it likely that tau is a major regulator of microtubule formation in cells.

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains.

Portions of tau proteins generated by in vitro translation were used to show that these repeats represent tubulin-binding domains, two of which are sufficient to bind to microtubules assembled from purified tubulin in the presence of taxol.

Presence of tau in isolated nuclei from human brain

Localization and in situ phosphorylation state of nuclear tau.

The results suggest that nuclear tau is not phosphorylated in the nucleus but rather in the cytosol prior to transport into the nucleus, which strongly suggests that it has a functional role inThe nucleus.

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau.

Tau generates a partially stable but still dynamic state in microtubules, which is perturbed by phosphorylation by MAP2 kinase, which affects all three activities by lowering the affinity of tau for the microtubule lattice.

A discrete repeated sequence defines a tubulin binding domain on microtubule-associated protein tau.

Tau function and dysfunction in neurons: its role in neurodegenerative disorders.

Alzheimer's disease is the most usual neurodegenerative disorder leading to dementia in the aged human population and NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau.