Alzheimer ’ s Disease : Interactions Between Cholinergic Functions and β-amyloid

@inproceedings{Yan2004AlzheimerS,
  title={Alzheimer ’ s Disease : Interactions Between Cholinergic Functions and β-amyloid},
  author={Zhen Yan and Jian Feng},
  year={2004}
}
Alzheimer’s disease (AD) is characterized by two major features: (1) degeneration of basal forebrain cholinergic neurons and ensuing deficient cholinergic functions in cortex and hippocampus; (2) extracellular protein aggregates containing β-amyloid peptides (Aβ) in these cholinergic target areas. So far, the most effective therapy for AD is to enhance cholinergic transmission. Neuromodulatory functions of the cholinergic system are mainly mediated by muscarinic receptors (mAChRs). It has long… CONTINUE READING