Alzheimer's disease.

@article{Querfurth2010AlzheimersD,
  title={Alzheimer's disease.},
  author={Henry W. Querfurth and Frank M LaFerla},
  journal={The New England journal of medicine},
  year={2010},
  volume={362 4},
  pages={
          329-44
        }
}
From the Department of Neurology, Caritas St. Elizabeth’s Medical Center, Brighton, MA (H.W.Q.); the Department of Neurology, Tufts Medical Center, Boston (H.W.Q.); the Department of Neurology, Rhode Island Hospital and the Warren Alpert Medical School at Brown University, Providence (H.W.Q.); and the Department of Neurobiology and Behavior, University of California, Irvine, Irvine (F.M.L.). Address reprint requests to Dr. Querfurth at the Department of Neurology, Rhode Island Hospital, 563… 

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References

SHOWING 1-10 OF 247 REFERENCES
Molecular genetics of Alzheimer's disease.
TLDR
Evidence is shown that Alzheimer's disease is a genetically heterogeneous disorder, and new approaches are delineated in the study of the etiological and pathogenetic mechanisms of Alzheimer’s disease.
Alzheimer's disease: genes, proteins, and therapy.
TLDR
Evidence that the presenilin proteins, mutations in which cause the most aggressive form of inherited AD, lead to altered intramembranous cleavage of the beta-amyloid precursor protein by the protease called gamma-secretase has spurred progress toward novel therapeutics and provided discrete biochemical targets for drug screening and development.
Age, neuropathology, and dementia.
TLDR
The association between the pathological features of Alzheimer's disease and dementia is stronger in younger old persons than in older old persons, and age must be taken into account when assessing the likely effect of interventions against dementia on the population.
Amyloid Angiopathy–Related Vascular Cognitive Impairment
TLDR
Data from patients with CAA-related intracerebral hemorrhage suggesting associations of CAA with radiographic white matter abnormalities and cognitive impairment highlight the importance of elucidating the effects of vascular amyloid on cerebrovascular function and of developing therapeutic strategies for this potentially widespread form of microvascular cognitive impairment.
Atherosclerosis of Cerebral Arteries in Alzheimer Disease
TLDR
It is hypothesized that AD pathology is the complex end result of slowly evolving vascular disease and parenchymal lesions and important treatment options and directions for additional interventions to stave off this dementia are suggested.
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
TLDR
Both linear regressions and multivariate analyses correlating three global neuropsychological tests with a number of structural and neurochemical measurements performed on a prospective series of patients with Alzheimer's disease and 9 neuropathologically normal subjects reveal very powerful correlations with all three psychological assays.
National Institute of Neurological Disorders and Stroke FIVE-YEAR STRATEGIC PLAN ON MINORITY HEALTH DISPARITIES
TLDR
The NINDS has scientific interests in neurological disorders as diverse as stroke, epilepsy, multiple sclerosis, head and spinal cord injuries, Alzheimer's disease and other dementias, Parkinson's disease, neurofibromatosis, muscular dystrophy, neuroAIDS, amyotrophic lateral sclerosis, and Huntington disease.
No disease in the brain of a 115-year-old woman
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
TLDR
The loss of neuronal connectivity, indexed by loss of synapses, predicted the degree of cognitive impairment in the patients who underwent biopsy and indicated a degree of structural change in AD brain not likely to be affected by pharmacotherapy.
...
1
2
3
4
5
...