Alzheimer's disease pathogenesis: role of aging.

  • Denham Harman
  • Published 2006 in Annals of the New York Academy of Sciences


Alzheimer's disease (AD) is the chief cause of dementia, and age is its major risk factor. The majority of cases (90-95%) are sporadic (SAD), and the remainder are familial (FAD). AD is characterized by two brain lesions, intraneuronal fibrillary tangles and extracellular plaques. The lesions are identical in SAD and FAD as well as to those in persons with… (More)