Alzheimer's disease

  title={Alzheimer's disease},
  author={K. Blennow and M. Leon and H. Zetterberg},
  journal={The Lancet},
Alzheimer's disease is the most common cause of dementia. Research advances have enabled detailed understanding of the molecular pathogenesis of the hallmarks of the disease--ie, plaques, composed of amyloid beta (Abeta), and tangles, composed of hyperphosphorylated tau. However, as our knowledge increases so does our appreciation for the pathogenic complexity of the disorder. Familial Alzheimer's disease is a very rare autosomal dominant disease with early onset, caused by mutations in the… Expand

Paper Mentions

Observational Clinical Trial
This research project will address a desperate need for evidence on how diet could be used to treat and improve symptoms of Alzheimer's disease (AD). It has been estimated that 36… Expand
ConditionsDementia Alzheimers
Synapses and Alzheimer's disease.
Epidemiology of Alzheimer disease
Inflammation and Alzheimer’s disease
The Pathogenesis of Alzheimers Disease—Is It a Lifelong “Calciumopathy”?
  • Grace E Stutzmann
  • Biology, Medicine
  • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2007
Variations in the neuropathology of familial Alzheimer’s disease
Epidemiology of Alzheimer Disease
Is AD a homogeneous nosologic entity? Yes
Aβ Toxicity in Alzheimer's Disease
Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease