Alzheimer's disease

@article{Blennow2006AlzheimersD,
  title={Alzheimer's disease},
  author={Kaj Blennow and Mony J. de Leon and Henrik Zetterberg},
  journal={The Lancet},
  year={2006},
  volume={368},
  pages={387-403}
}
Epidemiology of Alzheimer disease
TLDR
An overview of the criteria used in the diagnosis of Alzheimer disease is provided, highlighting how this disease is related to, but distinct from, normal aging.
Inflammation and Alzheimer’s disease
TLDR
This review is to assess the association between neuroinflammation and AD through discussion of a variety of experimental and clinical studies on AD and to review treatment strategies designed to treat or prevent AD.
The Pathogenesis of Alzheimers Disease—Is It a Lifelong “Calciumopathy”?
  • Grace E Stutzmann
  • Biology
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2007
TLDR
It is considered that AD pathogenesis reflects long-term calcium dysregulations that ultimately serve an enabling role in the disease process and “Calcinists” do not necessarily reject βAptist or Tauist doctrine, but rather believe that their genesis is associated with earlier calcium signaling Dysregulations.
Variations in the neuropathology of familial Alzheimer’s disease
TLDR
Additional frontotemporal neuronal loss in association with increased tau pathology appears unique to PSEN mutations, with mutations in exons 8 and 9 having enlarged cotton wool plaques throughout their cortex.
Epigenetic processes in Alzheimer's disease
Alzheimers Disease: Know The Risk Factors.
TLDR
An increasing amount of evidence suggests that lifestyle factors such as diet/nutrition, exercise, intellectual activity, and social engagement can affect someone's Alzheimer's disease, and maintaining a healthy life style may reduce the risk of developing AD.
Epidemiology of Alzheimer Disease
TLDR
The prevalence and incidence rates, the established environmental risk factors, and the protective factors are discussed, and genetic variants predisposing to disease are reviewed.
Is AD a homogeneous nosologic entity? Yes
TLDR
A disorder primarily affecting structures in medial temporal lobe, with accumulation of amyloid β and abnormal tau, neuritic plaques and tangles, progressive loss of memory and/or other cognitive deficits, ultimately resulting in dementia should be classified as AD.
Clinical significance of fluid biomarkers in Alzheimer’s Disease
TLDR
This paper presents the research and development of CSF and blood biomarkers for AD as well as their potential clinical significance and aims to better understand the complex heterogeneity of AD pathology.
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