Epidemiology of Alzheimer disease
- BiologyNature Reviews Neurology
An overview of the criteria used in the diagnosis of Alzheimer disease is provided, highlighting how this disease is related to, but distinct from, normal aging.
Mechanisms of neurodegeneration - Insights from familial Alzheimer's disease.
- BiologySeminars in cell & developmental biology
Inflammation and Alzheimer’s disease
- BiologyArchives of pharmacal research
This review is to assess the association between neuroinflammation and AD through discussion of a variety of experimental and clinical studies on AD and to review treatment strategies designed to treat or prevent AD.
The Pathogenesis of Alzheimers Disease—Is It a Lifelong “Calciumopathy”?
- BiologyThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
It is considered that AD pathogenesis reflects long-term calcium dysregulations that ultimately serve an enabling role in the disease process and “Calcinists” do not necessarily reject βAptist or Tauist doctrine, but rather believe that their genesis is associated with earlier calcium signaling Dysregulations.
Variations in the neuropathology of familial Alzheimer’s disease
- BiologyActa Neuropathologica
Additional frontotemporal neuronal loss in association with increased tau pathology appears unique to PSEN mutations, with mutations in exons 8 and 9 having enlarged cotton wool plaques throughout their cortex.
Epigenetic processes in Alzheimer's disease
- BiologyChromatin Signaling and Neurological Disorders
Alzheimers Disease: Know The Risk Factors.
An increasing amount of evidence suggests that lifestyle factors such as diet/nutrition, exercise, intellectual activity, and social engagement can affect someone's Alzheimer's disease, and maintaining a healthy life style may reduce the risk of developing AD.
Epidemiology of Alzheimer Disease
- Biology, Psychology
The prevalence and incidence rates, the established environmental risk factors, and the protective factors are discussed, and genetic variants predisposing to disease are reviewed.
Is AD a homogeneous nosologic entity? Yes
- BiologyJournal of Neural Transmission
A disorder primarily affecting structures in medial temporal lobe, with accumulation of amyloid β and abnormal tau, neuritic plaques and tangles, progressive loss of memory and/or other cognitive deficits, ultimately resulting in dementia should be classified as AD.
Clinical significance of fluid biomarkers in Alzheimer’s Disease
- BiologyPharmacological reports : PR
This paper presents the research and development of CSF and blood biomarkers for AD as well as their potential clinical significance and aims to better understand the complex heterogeneity of AD pathology.