Alzheimer's disease

@article{Ballard2011AlzheimersD,
  title={Alzheimer's disease},
  author={Clive G Ballard and Serge Gauthier and Anne Corbett and Carol Brayne and Dag Aarsland and Emma Jones},
  journal={The Lancet},
  year={2011},
  volume={377},
  pages={1019-1031}
}
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References

SHOWING 1-10 OF 125 REFERENCES

Cholesterol as a risk factor for Alzheimer's disease – epidemiological evidence

TLDR
This review aims at presenting current epidemiological data on serum cholesterol levels and dietary fat intake as risk factors for dementia/AD, and at discussing the reasons and significance of contradictions between various studies.

Imaging cerebral atrophy: normal ageing to Alzheimer's disease

New perspectives on Alzheimer's disease.

  • D. Price
  • Biology
    Annual review of neuroscience
  • 1986
TLDR
Investigations of animal models that recapitulate certain features of AD should provide new insights into the nature, mechanisms, and consequences of cellular pathology of specific systems.

Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study

Structural magnetic resonance imaging in the practical assessment of dementia: beyond exclusion

Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists.

TLDR
The guidelines presented are adapted from those used by many neuropathologists at Alzheimer's disease research centers participating in CERAD, the Consortium to Establish a Registry for Alzheimer's Disease.

AddNeuroMed—The European Collaboration for the Discovery of Novel Biomarkers for Alzheimer's Disease

TLDR
The development and design of AddNeuroMed and the progress toward the development of plasma markers show that plasma markers are feasible and animal models are valuable in biomarker research.

Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline

TLDR
This international guideline on dementia covers major aspects of diagnostic evaluation and treatment, with particular emphasis on the type of patient often referred to the specialist physician, and revised the recommendations for clinical diagnosis, blood tests, neuroimaging, electroencephalography, and cerebrospinal fluid analysis.
...