Alzheimer's disease – do tauists and baptists finally shake hands?

@article{Mudher2002AlzheimersD,
  title={Alzheimer's disease – do tauists and baptists finally shake hands?},
  author={A. Mudher and S. Lovestone},
  journal={Trends in Neurosciences},
  year={2002},
  volume={25},
  pages={22-26}
}
The amyloid cascade hypothesis has been the predominant model of molecular pathogenesis in Alzheimer's disease. The finding of tau mutations in other dementias has added weight to the hypothesis as it suggests that tau-pathology is a downstream but essential part of the dementing process. However, some observations remain difficult to reconcile with the hypothesis. In transgenic mice, for example, amyloid generation does not induce the predicted cascade and in man, plaques and tangles are… Expand
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