Alzheimer's disease – do tauists and baptists finally shake hands?

@article{Mudher2002AlzheimersD,
  title={Alzheimer's disease – do tauists and baptists finally shake hands?},
  author={Amritpal Mudher and Simon Lovestone},
  journal={Trends in Neurosciences},
  year={2002},
  volume={25},
  pages={22-26}
}
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TLDR
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  • 2011
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TLDR
The accumulation of -synuclein into filamentous inclusions appears to play a mechanistic role in the pathogenesis of several progressive neurological disorders including PD, dementia with LBs, Down’s syndrome, FAD, LB variant of AD, sporadic AD, multiple system atrophy, and other synucleinopathies.
Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer's Disease Neuropathology.
TLDR
The evidence stated here strengthens the idea that some individuals are more resistant to AD pathology, or at least show an elongation of the asymptomatic state of the disease compared to others.
A critical analysis of the 'amyloid cascade hypothesis'.
TLDR
It was concluded that it is doubtful whether there is a direct causal link between Aβ and tau, and SP and NFT may not be directly related to the development of dementia, and transgenic models involving APP alone do not completely replicate AD pathology.
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