Alzheimer's Disease: Targeting the Cholinergic System

  title={Alzheimer's Disease: Targeting the Cholinergic System},
  author={Talita H{\'e}len Ferreira-Vieira and Isabella M. Guimaraes and Fl{\'a}via Rodrigues de Oliveira Silva and Fabiola M Ribeiro},
  booktitle={Current neuropharmacology},
Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl-CoA and choline in the cytoplasm and the vesicular acetylcholine transporter (VAChT) uptakes the neurotransmitter into synaptic vesicles. Following depolarization, ACh undergoes exocytosis reaching the synaptic cleft, where it can bind its receptors, including muscarinic and nicotinic receptors. ACh present at the… CONTINUE READING
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