Alzheimer's β‐amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

@article{Kurochkin1994AlzheimersP,
  title={Alzheimer's $\beta$‐amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme},
  author={Igor Kurochkin and Sataro Goto},
  journal={FEBS Letters},
  year={1994},
  volume={345}
}
The Degradation of Amyloid β as a Therapeutic Strategy in Alzheimer's Disease and Cerebrovascular Amyloidoses
TLDR
Recent findings on brain proteases capable of degrading amyloid β with a special focus on those enzymes for which there is genetic, transgenic or biochemical evidence suggesting that they may participate in the proteolysis of amyloids β in vivo are summarized.
Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation*
TLDR
It is concluded that a principal protease capable of down-regulating the levels of secreted Aβ extracellularly is IDE, and activity was unexpectedly found be associated with a time-dependent oligomerization of synthetic Aβ at physiological levels in the conditioned media of cultured cells.
Amyloid β Degradation: A Challenging Task for Brain Peptidases
TLDR
Recent findings on brain proteases capable of degrading Aβ are summarized, with a special focus on those enzymes for which there is genetic, transgenic or biochemical evidence supporting a role in the proteolysis of Aβ in vivo.
Proteolytic Degradation of the Amyloid β-Protein: The Forgotten Side of Alzheimers Disease
TLDR
A review explores the historical factors that obscured this important aspect of amyloidogenesis, and discusses the many fresh insights it offers into the causes of and potential treatments for AD.
Degradation of Alzheimer's ß-Amyloid Protein by Human and Rat Brain Peptidases: Involvement of Insulin-Degrading Enzyme
TLDR
Insulin-degrading enzyme is the main soluble ß-amyloid degrading enzyme at neutral pH in human brain and this activity was inhibited by pepstatin, implicating an aspartyl protease.
Analysis of β-Amyloid Peptide Degradation In Vitro.
TLDR
This chapter focuses on specific approaches to clarifying Aβ peptide-clearance mechanisms, which may potentially contribute to increased levels and to the development of insoluble Aβ deposits in the brains of afflicted individuals.
Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in Alzheimer's disease?
TLDR
The elderly with probable AD had lower serum substrate V degradation activity compared with those who had vascular dementia, and the blood proteases mediating Aβ degradation may be important for the AD pathogenesis.
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