Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

  title={Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?},
  author={Heiko Braak and Kelly del Tredici},
  journal={Acta Neuropathologica},
There is increasing interest in the early phase of Alzheimer’s disease before severe neuronal dysfunction occurs, but it is still not known when or where in the central nervous system the underlying pathological process begins. In this review, we discuss the idea of possible disease progression from the locus coeruleus to the transentorhinal region of the cerebral cortex via neuron-to-neuron transmission and transsynaptic transport of tau protein aggregates, and we speculate that such a… CONTINUE READING
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