Alzheimer’s disease risk genes in wild-type adult zebrafish exhibit gender-specific expression changes during aging

@article{Lee2016AlzheimersDR,
  title={Alzheimer’s disease risk genes in wild-type adult zebrafish exhibit gender-specific expression changes during aging},
  author={Jin-young Lee and Samuel M. Peterson and Jennifer L. Freeman},
  journal={neurogenetics},
  year={2016},
  volume={17},
  pages={197-199}
}
  • Jin-young Lee, Samuel M. Peterson, Jennifer L. Freeman
  • Published in neurogenetics 2016
  • Biology, Medicine
  • To the editor: Alzheimer’s disease (AD) is a neurodegenerative disease and the most common type of dementia. It is recognized that certain genetic factors involved in formation of amyloid plaques (an AD pathological hallmark) including amyloid-β protein precursor (APP, zebrafish appa and appb) and presenilins (zebrafish psen1 and psen2), and also apolipoprotein E (APOE, zebrafish apoea and apoeb) play a role in elevating the risk for AD [1]. However, the pathogenic mechanisms related with the… CONTINUE READING

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