Alzheimer’s disease

@article{Burns2009AlzheimersD,
  title={Alzheimer’s disease},
  author={A. Burns and S. Iliffe},
  journal={BMJ : British Medical Journal},
  year={2009},
  volume={338}
}
In this, the second of two review articles about dementia, we focus on Alzheimer’s disease, which is the most common cause of dementia. Dementia is a clinical syndrome characterised by a cluster of symptoms and signs manifested by difficulties in memory, disturbances in language, psychological and psychiatric changes, and impairments in activities of daily living. Alzheimer’s disease is a specific disease that affects about 6% of the population aged over 65 and increases in incidence with age… Expand
Alzheimer’s Dementia: An Overview
TLDR
Targeting these lifestyle-related factors in young adulthood and middle age may be protective against AD, as high educational achievement in early life, involvement in cognitively stimulating activity, physical activity and social engagement have been associated with reduced risk of late-life dementia and AD. Expand
Posterior cortical atrophy variant of Alzheimer's dementia-A case report.
TLDR
A middle aged gentlemen presenting with clinical features suggestive of Posterior cortical atrophy is described, which poses challenge to clinicians in diagnosing at initial stages. Expand
Diagnosis and Management of the Patient with Suspected Dementia in Primary Care
TLDR
This review summarises the epidemiology of dementia syndrome, and offers detailed evidence-based advice on recognition of dementia (including subtyping) and responses to it and its associated symptoms. Expand
Alzheimer’s Disease and Herbal Combination Therapy: A Comprehensive Review
TLDR
The priority in AD research has remained to develop disease-modifying and development-reducing drugs for treatment regimens followed during the early and later stages, respectively. Expand
Dementia and imaging: the basics
Abstract Dementia is becoming more common as the population ages. We review the prevalence of different causes of dementia. Alzheimer's disease heads the list, followed by vascular dementia, LewyExpand
Biomarkers in Mild Stages of Alzheimer’s disease: Utility in clinical practice and their relation with nutritional and lifestyle factors
TLDR
The utility of biomarkers in AD and nutritional and lifestyle factors  used as treatment in mild stages are described and their utility in clinical practice relating this with nutritional andifestyle factors as possible treatment is defined. Expand
Prevalence of Frailty in Mild to Moderate Alzheimer's Disease: A Systematic Review and Meta-analysis.
TLDR
It was showed that frailty is highly prevalent in older patients with Alzheimer's disease in the community with the pooled prevalence of 31.9% and the true prevalence may be much higher given that end-stage patients may not be included. Expand
[Truth telling of Alzheimer's disease diagnosis].
TLDR
The current state of literature on diagnostic truth telling in dementia is reported, the ethical principles involved are reviewed, and a strategy to address the issue is given. Expand
Combination Therapy for Alzheimer’s Disease
TLDR
It is shown that combination therapy for AD seems to be safe, well tolerated and may represent the current gold standard for treatment of moderate to severe AD and possibly mild to moderate AD as well. Expand
Management of Depression in Patients with Dementia: Is Pharmacological Treatment Justified?
TLDR
This review aims to provide a concise overview of pharmacological treatments for depression in dementia and preliminary evidence supports a role of adequate analgesia in improving mood in people with dementia. Expand
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