Alzheimer’s disease

@article{Burns2009AlzheimersD,
  title={Alzheimer’s disease},
  author={Alistair Burns and Steve Iliffe},
  journal={BMJ : British Medical Journal},
  year={2009},
  volume={338}
}
  • A. Burns, S. Iliffe
  • Published 5 February 2009
  • Psychology, Medicine
  • BMJ : British Medical Journal
In this, the second of two review articles about dementia, we focus on Alzheimer’s disease, which is the most common cause of dementia. Dementia is a clinical syndrome characterised by a cluster of symptoms and signs manifested by difficulties in memory, disturbances in language, psychological and psychiatric changes, and impairments in activities of daily living. Alzheimer’s disease is a specific disease that affects about 6% of the population aged over 65 and increases in incidence with age… 
Alzheimer’s Dementia: An Overview
TLDR
Targeting these lifestyle-related factors in young adulthood and middle age may be protective against AD, as high educational achievement in early life, involvement in cognitively stimulating activity, physical activity and social engagement have been associated with reduced risk of late-life dementia and AD.
The Systemic Effects of Exercise on the Systemic Effects of Alzheimer’s Disease
TLDR
The systemic effects of both regular exercise and AD are summarized and it is pointed out how common exercise-induced adaptation via peripheral organs can decrease the incidence of AD or attenuate the progress of AD.
Alzheimer’s Disease and Herbal Combination Therapy: A Comprehensive Review
TLDR
The priority in AD research has remained to develop disease-modifying and development-reducing drugs for treatment regimens followed during the early and later stages, respectively.
Towards a Consensus on Alzheimer’s Disease Comorbidity?
TLDR
Interestingly, the comorbid diseases are often degenerative diseases exacerbated by reactive oxygen species, thus underlining the potential role of antioxidants in the treatment of AD and comor bid diseases.
Amyloid beta hypothesis in Alzheimer's disease: Major culprits and recent therapeutic strategies.
TLDR
Some of the state of the art knowledge on the functional aspects of the key players involved in the amyloid hypothesis are presented and anti-amyloid agents present in the Phase III clinical trials are discussed.
Biomarkers in Mild Stages of Alzheimer’s disease: Utility in clinical practice and their relation with nutritional and lifestyle factors
TLDR
The utility of biomarkers in AD and nutritional and lifestyle factors  used as treatment in mild stages are described and their utility in clinical practice relating this with nutritional andifestyle factors as possible treatment is defined.
Prevalence of Frailty in Mild to Moderate Alzheimer's Disease: A Systematic Review and Meta-analysis.
TLDR
It was showed that frailty is highly prevalent in older patients with Alzheimer's disease in the community with the pooled prevalence of 31.9% and the true prevalence may be much higher given that end-stage patients may not be included.
Drug development for Alzheimer’s disease: review
TLDR
The recent advance in AD drug development was reviewed and drug discovery programs under clinical trials targeting cholinergic system, α7 nicotinic acetylcholine receptors, N-methyl-d-aspartate receptor, β-secretase, γ- secretase modulators, tau, inflammatory mediators and glucagon-like peptide-1 (GLP-1) were discussed.
[Truth telling of Alzheimer's disease diagnosis].
TLDR
The current state of literature on diagnostic truth telling in dementia is reported, the ethical principles involved are reviewed, and a strategy to address the issue is given.
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