Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein

@article{Goedert2015AlzheimersAP,
  title={Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein},
  author={Michel Goedert},
  journal={Science},
  year={2015},
  volume={349}
}
The pathological assembly of Aβ, tau, and α-synuclein is at the heart of Alzheimer’s and Parkinson’s diseases. Extracellular deposits of Aβ and intraneuronal tau inclusions define Alzheimer’s disease, whereas intracellular inclusions of α-synuclein make up the Lewy pathology of Parkinson’s disease. Most cases of disease are sporadic, but some are inherited in a dominant manner. Mutations frequently occur in the genes encoding Aβ, tau, and α-synuclein. Overexpression of these mutant proteins can… CONTINUE READING
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