Alzheimer’s Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes

@inproceedings{Gynther2018AlzheimersDP,
  title={Alzheimer’s Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes},
  author={Mikko Gynther and Elena Puris and Soile Peltokangas and Seppo Auriola and Katja M Kanninen and Jari Koistinaho and Kristiina M Huttunen and Marika Ruponen and Kati-Sisko Vellonen},
  booktitle={Pharmaceutical Research},
  year={2018}
}
PurposeThe study aim was to evaluate the effect of Alzheimer’s disease (AD) and inflammatory insult on the function of L-type amino acid transporter 1 (Lat1) at the mouse blood-brain barrier (BBB) as well as Lat1 function and expression in mouse primary astrocytes.MethodsThe Lat1 function and expression was determined in wildtype astrocytes with and without lipopolysaccharide (LPS)-induced inflammation and in LPS treated AD APP/PS1 transgenic astrocytes. The function of Lat1 at the BBB was… CONTINUE READING
BETA
1
Twitter Mention

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

BanksWA, AM Gray, +4 authors disruption et al. Lipopolysaccharide-induced blood-brain barrier
  • J Neuroinflammation. 2015;12:223. 17 Page 8 of 8 Pharm Res
  • 2019
VIEW 1 EXCERPT