Alzheimer's disease. Morbid risk among first-degree relatives approximates 50% by 90 years of age.

@article{Mohs1987AlzheimersDM,
  title={Alzheimer's disease. Morbid risk among first-degree relatives approximates 50% by 90 years of age.},
  author={Richard C. Mohs and John C. S. Breitner and Jeremy M. Silverman and Kenneth L. Davis},
  journal={Archives of general psychiatry},
  year={1987},
  volume={44 5},
  pages={405-8}
}
The morbid risk of Alzheimer's disease was studied in first-degree relatives of 50 patients who met contemporary clinical research diagnostic criteria and 45 matched controls. Relatives of patients showed a 46% cumulative incidence of probable Alzheimer's disease by 86 years of age. The risk, which was four times the control value, is consistent with other recent reports using similar, modern methods. Although not conclusive, the data suggest the operation of a relatively common, dominant… CONTINUE READING

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