Alzheimer's disease selective vulnerability and modeling in transgenic mice.

@article{Gtz2009AlzheimersDS,
  title={Alzheimer's disease selective vulnerability and modeling in transgenic mice.},
  author={J{\"u}rgen G{\"o}tz and Nicole Schonrock and Bryce Vissel and Lars M Ittner},
  journal={Journal of Alzheimer's disease : JAD},
  year={2009},
  volume={18 2},
  pages={
          243-51
        }
}
Neurodegenerative diseases are characterized by 'hot spots' of degeneration. The regions of primary vulnerability vary between different neurodegenerative diseases. Within these regions, some neurons are lost whereas others that are morphologically indiscriminate survive. The enigma of this selective vulnerability is tightly linked to two fundamental problems in the neurosciences. First, it is not understood how many neuronal cell types make up the mammalian brain; estimates are in the order of… CONTINUE READING

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