Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment

  title={Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment},
  author={Eva Louwersheimer and Steffen Wolfsgruber and Ana Carolina Espinosa and Andr{\'e} Lacour and Stefanie Heilmann-Heimbach and Montserrat Alegret and Isabel Hern{\'a}ndez and Mait{\'e}e Rosende-Roca and Llu{\'i}s T{\'a}rraga and Merç{\'e} Boada and Johannes Kornhuber and Oliver Peters and Lutz Fr{\"o}lich and Michael Huell and Eckart Ruether and Jens Wiltfang and Martin Scherer and Steffi G Riedel-Heller and Frank Jessen and Markus M. N{\"o}then and Wolfgang Maier and Ted Koene and Philip Scheltens and Henne Holstege and Michael Wagner and Agust{\'i}n Ru{\'i}z and Wiesje M. van der Flier and Tim Becker and Alfredo Ramirez},
  journal={Alzheimer's & Dementia},
INTRODUCTION We evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI). METHODS We selected 1730 MCI patients from four independent data sets. Weighted polygenic risk scores (PGS) were constructed of 18 non-apolipoprotein E (APOE) AD risk variants. In addition, we determined APOE genotype. AD endophenotypes were cognitive decline over time and cerebrospinal fluid (CSF) biomarkers… CONTINUE READING