Alzheimer's disease pathology does not mediate the association between depressive symptoms and subsequent cognitive decline

@article{Royall2013AlzheimersDP,
  title={Alzheimer's disease pathology does not mediate the association between depressive symptoms and subsequent cognitive decline},
  author={Donald R Royall and Raymond F Palmer},
  journal={Alzheimer's & Dementia},
  year={2013},
  volume={9},
  pages={318-325}
}
BACKGROUND Depressive symptoms in nondemented individuals appear to hasten the progression from mild cognitive impairment to clinical Alzheimer's disease (AD) and double the risk of incident AD. However, the mechanism(s) by which depression might affect this risk has not been well established. The purpose of this analysis was to test the hypothesis that AD pathology mediates depression's apparent effect on the risk of dementia conversion using longitudinally collected psychometric testing and… CONTINUE READING
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