Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.

@article{FornyGermano2014AlzheimersDP,
  title={Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.},
  author={Let{\'i}cia Forny-Germano and Natalia de M. Lyra e Silva and Andr{\'e} Filipe de Moraes Batista and Jordano Brito-Moreira and Matthias Gralle and Susan E. Boehnke and Brian C. Coe and Ann Lablans and Sofia Alexandra Marques and Ana Maria Blanco Martinez and William Leon Klein and Jean-Christophe Houzel and S{\'e}rgio T. Ferreira and Douglas P. Munoz and Fernanda G De Felice},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 41},
  pages={
          13629-43
        }
}
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a major medical problem. Here, we have investigated the impact of amyloid-β (Aβ) oligomers, AD-related neurotoxins, in the brains of rats and adult nonhuman primates (cynomolgus macaques). Soluble Aβ oligomers are known to accumulate in the brains of AD patients and correlate with disease-associated cognitive dysfunction. When injected into the lateral ventricle of rats and macaques, Aβ oligomers diffused into the brain… CONTINUE READING

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