Alzheimer's disease-like pathology in senescence-accelerated OXYS rats can be partially retarded with mitochondria-targeted antioxidant SkQ1.

@article{Stefanova2014AlzheimersDP,
  title={Alzheimer's disease-like pathology in senescence-accelerated OXYS rats can be partially retarded with mitochondria-targeted antioxidant SkQ1.},
  author={Natalia A. Stefanova and Natalia A. Muraleva and Vladimir P. Skulachev and Nataliya G. Kolosova},
  journal={Journal of Alzheimer's disease : JAD},
  year={2014},
  volume={38 3},
  pages={681-94}
}
We previously showed that mitochondria-targeted antioxidant SkQ1 (plastoquinonyl-decyltriphenylphosphonium) at nanomolar concentrations is capable of preventing and slowing down some cerebral dysfunctions in accelerated-senescence OXYS rats. Here we demonstrate that OXYS rats develop behavior, learning, and memory deficits against a background of neurodegeneration signs detected by magnetic resonance tomography and amyloid-β (Aβ) pathology similar to those seen in Alzheimer's disease (AD). Long… CONTINUE READING
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OXYS rats: A prospective model for evaluation of antioxidant availability in prevention and therapy of accelerated aging and age-related cognitive decline

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