Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels

@article{Khler2005AlzheimersDN,
  title={Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels},
  author={Christoph K{\"o}hler and Ulrich Ebert and Karlheinz Baumann and Hannsj{\"o}rg Schr{\"o}der},
  journal={Neurobiology of Disease},
  year={2005},
  volume={20},
  pages={528-540}
}
Most transgenic mice used for preclinical evaluation of potential disease-modifying treatments of Alzheimer's disease develop major histopathological features of this disease by several-fold overexpression of the human amyloid precursor protein. We studied the phenotype of three different strains of gene-targeted mice which express the amyloid precursor protein at endogenous levels. Only further crossing with transgenic mice overexpressing mutant human presenilin1 led to the deposition of… CONTINUE READING
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