Alzheimer's disease in late-life dementia: a minor toxic consequence of devastating cerebrovascular dysfunction.

@article{HenryFeugeas2008AlzheimersDI,
  title={Alzheimer's disease in late-life dementia: a minor toxic consequence of devastating cerebrovascular dysfunction.},
  author={Marie C{\'e}cile Henry-Feugeas},
  journal={Medical hypotheses},
  year={2008},
  volume={70 4},
  pages={866-75}
}
Alzheimer's disease (AD) is thought to be the most common cause of late-life dementia. But pure AD is infrequent whereas AD pathology is often insufficient to explain dementia in the elderly. Conversely, cerebrovascular disease is omnipresent and the crucial role of microvascular alterations increasingly recognized in late dementia or "Alzheimer syndrome". Pathomechanisms of vascular cognitive impairment are still debated but recent data indicate that the initial concept of chronic low grade… CONTINUE READING

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