Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures.

@article{Westmark2010AlzheimersDA,
  title={Alzheimer's disease and Down syndrome rodent models exhibit audiogenic seizures.},
  author={Cara J Westmark and Pamela R. Westmark and James S Malter},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={20 4},
  pages={
          1009-13
        }
}
Amyloid-beta protein precursor (AbetaPP) is overexpressed in Alzheimer's disease (AD), Down syndrome (DS), autism, and fragile X syndrome. Seizures are a common phenotype in all of these neurological disorders, yet the underlying molecular mechanism(s) of seizure induction and propagation remain largely unknown. We demonstrate that AD (Tg2576) and DS (Ts65Dn) mice exhibit audiogenic seizures, which can be attenuated with antagonists to metabotropic glutamate receptor 5 (mGluR5) or by passive… CONTINUE READING

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