Alzheimer's disease and Creutzfeldt-Jakob disease: overlap of pathogenic mechanisms.

@article{DeArmond1993AlzheimersDA,
  title={Alzheimer's disease and Creutzfeldt-Jakob disease: overlap of pathogenic mechanisms.},
  author={Stephen J. DeArmond},
  journal={Current opinion in neurology},
  year={1993},
  volume={6 6},
  pages={
          872-81
        }
}
This article compares beta-amyloid precursor protein (beta-APP) disorders exemplified by Alzheimer's disease (AD), with prion protein (PrP) disorders, exemplified by Creutzfeldt-Jakob disease (CJD) in humans and scrapie in animals. Although there are obvious differences in the etiology and pathogenesis of both sets of disorders, a remarkable number of similarities exist. Both sets of disorders are characterized clinically by age-related sporadic and familial diseases. In both, an abnormal form… CONTINUE READING
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