Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

  title={Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts},
  author={Gerald M{\"u}nch and Reinhard Schinzel and Claudia Loske and Adrianne Wong and N{\'u}ria Durany and Juan Li and Helen Vlassara and Mark A. Smith and George Perry and Peter Franz Riederer},
  journal={Journal of Neural Transmission},
Many approaches have been undertaken to understand Alzheimer's disease (AD) but the heterogeneity of the etiologic factors makes it difficult to define the clincally most important factor determining the onset and progression of the disease. However, there is increasing evidence that the previously so-called "secondary factors" such as a disturbed glucose metabolism, oxidative stress and formation of "advanced glycation endproducts" (AGEs) and their interaction in a vicious cycle are also… CONTINUE READING


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