Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD.

@article{Wu2008AlzheimersD,
  title={Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD.},
  author={Jinfang Wu and Md Riyaz Basha and Brian Brock and David P Cox and Fernando Cardozo-Pelaez and Christopher A. McPherson and Jean Harry and Deborah C. Rice and Bryan Maloney and Demao Chen and Debomoy K. Lahiri and Nasser H. Zawia},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 1},
  pages={3-9}
}
The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead (Pb) during brain development predetermined the expression and regulation of the amyloid precursor protein (APP) and its amyloidogenic beta-amyloid (Abeta) product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 (beta… CONTINUE READING
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Genes are not our destiny: the somatic epitype bridges between the genotype and the phenotype

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  • 2007
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