Alzheimer's disease: the relationship between the density of senile plaques, neurofibrillary tangles and A4 protein in human patients.

@article{Armstrong1991AlzheimersDT,
  title={Alzheimer's disease: the relationship between the density of senile plaques, neurofibrillary tangles and A4 protein in human patients.},
  author={Richard A Armstrong and D. Myers and Chelsey M. Smith and Nigel J. Cairns and Philip J. Luthert},
  journal={Neuroscience letters},
  year={1991},
  volume={123 2},
  pages={141-3}
}
The numerical density of senile plaques (SP) and neurofibrillary tangles (NFT) as revealed by the Glees silver method was compared with SP and NFT revealed by the Gallyas method and with amyloid (A4) deposits in immunostained sections in 6 elderly cases of Alzheimer's disease. The density of NFT was generally greater and A4 lower in tissue from hippocampus compared with the neocortex suggesting that A4 deposition was less important than the degree of paired helical filament (PHF) related damage… CONTINUE READING

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