Alzheimer's disease: interaction of apolipoprotein E genotype, family history of dementia, gender, education, ethnicity, and age of onset.

@article{Duara1996AlzheimersDI,
  title={Alzheimer's disease: interaction of apolipoprotein E genotype, family history of dementia, gender, education, ethnicity, and age of onset.},
  author={Ranjan Duara and Warren Barker and Robert Lopez-Alberola and David A. Loewenstein and Luis Grau and Dawna Gilchrist and Steven Sevush and S St George-Hyslop},
  journal={Neurology},
  year={1996},
  volume={46 6},
  pages={1575-9}
}
We evaluated 197 patients with predominantly late-onset Alzheimer's disease (AD) who belonged to several ethnic groups and analyzed the relationship of age of onset of AD to the presence or absence of several risk factors in this entire group of patients. The apolipoprotein E (apoE) epsilon 4 allele frequency, which was 29% in all patients (compared with the reported population mean of 13.7%, p < 0.001, did not vary significantly between ethnic groups but declined significantly with increasing… CONTINUE READING

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