Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments.

@article{Delacourte1986AlzheimersDT,
  title={Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments.},
  author={Andr{\'e} Delacourte and Andr{\'e} Defossez},
  journal={Journal of the neurological sciences},
  year={1986},
  volume={76 2-3},
  pages={173-86}
}
A rabbit antiserum was raised against paired helical filaments (PHF). This antiserum stains specifically neurofibrillary tangles (NFT) at the light-microscopic level and PHF at the electron-microscopic level in sections of Alzheimer neocortex and hippocampus. We studied the nature of the antigens recognized by this antiserum by immunocytochemistry, immunoblots and immunoadsorption. These approaches showed that the anti-PHF specifically labels a set of low molecular weight 65-50 kDa microtubule… CONTINUE READING

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