Alzheimer's disease, a multifactorial disorder seeking multitherapies.

  title={Alzheimer's disease, a multifactorial disorder seeking multitherapies.},
  author={Khalid Iqbal and Inge Grundke-Iqbal},
  journal={Alzheimer's & dementia : the journal of the Alzheimer's Association},
  volume={6 5},
Alzheimer's disease (AD) is multifactorial and apparently involves several different etiopathogenic mechanisms. There are at least five subgroups of AD based on cerebrospinal fluid levels of Abeta(1-42), a marker of beta-amyloid (Abeta) plaques, and tau and ubiquitin, two markers of neurofibrillary tangles. These different AD subgroups may respond differently to a given disease-modifying drug, and hence, different therapeutic drugs for different disease subgroups might be required… CONTINUE READING


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