Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions

@article{Ohgami1992AlzheimersAP,
  title={Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions},
  author={Tetsuya Ohgami and Tetsuyuki Kitamoto and Jun Tateishi},
  journal={Neuroscience Letters},
  year={1992},
  volume={136},
  pages={75-78}
}
By using a monoclonal antibody and polyclonal antibodies to human beta amyloid precursor protein (APP), we immunohistochemically examined axonal swellings (spheroids). The immunoreactivity of APP was observed in numerous spheroids, which were found around the areas of old cerebral infarctions, in the globus pallidus with Hallervorden-Spatz disease as well as in or around brain abscesses. The axonal swellings were not immunolabeled with beta protein. These results implied that APP accumulated in… CONTINUE READING
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