Alzheimer's Disease-related Overexpression of the Cation-dependent Mannose 6-Phosphate Receptor Increases A Secretion

@inproceedings{Mathews2002AlzheimersDO,
  title={Alzheimer's Disease-related Overexpression of the Cation-dependent Mannose 6-Phosphate Receptor Increases A Secretion},
  author={Paul M. Mathews and Carolyn B. Guerra and Ying Jiang and Olivera M. Grbovic and Benjamin H. Kao and Stephen D Schmidt and Ravi Dinakar and Marc Mercken and Annette Hille-Rehfeld and Jack Rohrer and Pankash D. Mehta and Anne M. Cataldo and Ralph A. Nixon},
  year={2002}
}
Prominent endosomal and lysosomal changes are an invariant feature of neurons in sporadic Alzheimer’s disease (AD). These changes include increased levels of lysosomal hydrolases in early endosomes and increased expression of the cation-dependent mannose 6-phosphate receptor (CD-MPR), which is partially localized to early endosomes. To determine whether AD-associated redistribution of lysosomal hydrolases resulting from changes in CD-MPR expression affects amyloid precursor protein (APP… CONTINUE READING