Alx3-deficient mice exhibit decreased insulin in beta cells, altered glucose homeostasis and increased apoptosis in pancreatic islets

@article{Mirasierra2010Alx3deficientME,
  title={Alx3-deficient mice exhibit decreased insulin in beta cells, altered glucose homeostasis and increased apoptosis in pancreatic islets},
  author={Mercedes Mirasierra and Antonio J Fernandez-Perez and Natacha D{\'i}az-Prieto and Mario Vallejo},
  journal={Diabetologia},
  year={2010},
  volume={54},
  pages={403-414}
}
Homeodomain transcription factors play an important role in the regulation of pancreatic islet function. In previous studies we determined that aristaless-like homeobox 3 (ALX3) is produced in islet cells, binds to the promoter of the insulin gene and regulates its expression. The purpose of the present study was to investigate the functional role of ALX3 in pancreatic islets and its possible involvement in the regulation of glucose homeostasis in vivo. Alx3-knockout mice were used. Glucose and… CONTINUE READING

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