Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis.

@article{McKleroy2013AlwaysCU,
  title={Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis.},
  author={William McKleroy and Ting-Hein Lee and Kamran Atabai},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2013},
  volume={304 11},
  pages={L709-21}
}
Pulmonary fibrosis is a vexing clinical problem with no proven therapeutic options. In the normal lung there is continuous collagen synthesis and collagen degradation, and these two processes are precisely balanced to maintain normal tissue architecture. With lung injury there is an increase in the rate of both collagen production and collagen degradation. The increase in collagen degradation is critical in preventing the formation of permanent scar tissue each time the lung is exposed to… CONTINUE READING
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