Alveolar wall apoptosis causes lung destruction and emphysematous changes.

  title={Alveolar wall apoptosis causes lung destruction and emphysematous changes.},
  author={Kazutetsu Aoshiba and Naoko Yokohori and Atsushi Nagai},
  journal={American journal of respiratory cell and molecular biology},
  volume={28 5},
Pulmonary emphysema is characterized by alveolar wall destruction and airspace enlargement. Recent evidence indicates that epithelial or endothelial apoptosis may be involved in the pathogenesis of emphysema. Here, we describe the induction of emphysematous changes, including airspace enlargement, alveolar wall destruction, and enhanced lung distensibility, in mice receiving a single intratracheal injection of active caspase-3 and Chariot, a newly developed protein transfection reagent… CONTINUE READING
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