Alveolar progenitor and stem cells in lung development, renewal and cancer

@article{Desai2014AlveolarPA,
  title={Alveolar progenitor and stem cells in lung development, renewal and cancer},
  author={Tushar J Desai and Douglas G Brownfield and Mark A Krasnow},
  journal={Nature},
  year={2014},
  volume={507},
  pages={190-194}
}
Alveoli are gas-exchange sacs lined by squamous alveolar type (AT) 1 cells and cuboidal, surfactant-secreting AT2 cells. Classical studies suggested that AT1 arise from AT2 cells, but recent studies propose other sources. Here we use molecular markers, lineage tracing and clonal analysis to map alveolar progenitors throughout the mouse lifespan. We show that, during development, AT1 and AT2 cells arise directly from a bipotent progenitor, whereas after birth new AT1 cells derive from rare, self… CONTINUE READING
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