Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype.

@article{Lugogo2012AlveolarMF,
  title={Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype.},
  author={Njira L. Lugogo and John W. Hollingsworth and Druhan L Howell and Loretta G. Que and Dave C Francisco and Tony D. Church and Erin N. Potts-Kant and Jennifer L Ingram and Ying Wang and Sin-Ho Jung and Monica Kraft},
  journal={American journal of respiratory and critical care medicine},
  year={2012},
  volume={186 5},
  pages={404-11}
}
RATIONALE Obesity is associated with increased prevalence and severity of asthma. Adipose tissue macrophages can contribute to the systemic proinflammatory state associated with obesity. However, it remains unknown whether alveolar macrophages have a unique phenotype in overweight/obese patients with asthma. OBJECTIVES We hypothesized that leptin levels would be increased in the bronchoalveolar lavage fluid from overweight/obese subjects and, furthermore, that leptin would alter the response… CONTINUE READING
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Leptin enhances IL-6 production by human airway macrophages in obese asthma subjects [abstract

  • NL Lugogo, MJ Huggins, +5 authors M. Kraft
  • Am J Respir Crit Care Med 2011;183:A2673
  • 2011
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