Alveolar macrophages from normal subjects lack the NOS-related system y+ for arginine transport.

@article{Rotoli2007AlveolarMF,
  title={Alveolar macrophages from normal subjects lack the NOS-related system y+ for arginine transport.},
  author={Bianca Maria Rotoli and Valeria Dall'asta and Amelia Barilli and Raffaele D'Ippolito and Annalisa Tipa and Dario Olivieri and Gian Carlo Gazzola and Ovidio Bussolati},
  journal={American journal of respiratory cell and molecular biology},
  year={2007},
  volume={37 1},
  pages={105-12}
}
Systems y+ and y+L represent the main routes for arginine transport in mammalian cells. While system y+ activity is needed for the stimulated NO production in rodent alveolar macrophages (AM), no information is yet available about arginine transport in human AM. We study here arginine influx and genes for arginine transporters in AM from bronchoalveolar lavage of normal subjects. These cells express the y+ -related genes SLC7A1/CAT1 and SLC7A2/CAT2B, as well as the y+L genes SLC7A7/y+LAT1 and… CONTINUE READING

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