Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury.

@article{Frank2006AlveolarMC,
  title={Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury.},
  author={James A. Frank and Charlie M Wray and D F Mcauley and Reto Albert Schwendener and Michael A. Matthay},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={291 6},
  pages={L1191-8}
}
In patients requiring mechanical ventilation for acute lung injury or acute respiratory distress syndrome (ARDS), tidal volume reduction decreases mortality, but the mechanisms of the protective effect have not been fully explored. To test the hypothesis that alveolar macrophage activation is an early and critical event in the initiation of ventilator-induced lung injury (VILI), rats were ventilated with high tidal volume (HV(T)) for 10 min to 4 h. Alveolar macrophage counts in bronchoalveolar… CONTINUE READING