Alveolar macrophages are critical for the inhibition of allergic asthma by mesenchymal stromal cells.

@article{Mathias2013AlveolarMA,
  title={Alveolar macrophages are critical for the inhibition of allergic asthma by mesenchymal stromal cells.},
  author={Louisa J. Mathias and Sacha M. L. Khong and Lisa Spyroglou and Natalie L. Payne and Christopher Siatskas and Alison N. Thorburn and Richard L. Boyd and Tracy S. P. Heng},
  journal={Journal of immunology},
  year={2013},
  volume={191 12},
  pages={5914-24}
}
Multipotent mesenchymal stromal cells (MSCs) possess reparative and immunoregulatory properties, making them attractive candidates for cellular therapy. However, the majority of MSCs administered i.v. encounter a pulmonary impasse and soon disappear from the lungs, raising the question of how they induce such durable immunosuppressive effects. Using a mouse model of allergic asthma, we show that administration of MSCs isolated from human bone marrow, umbilical cord, or adipose tissue provoked a… CONTINUE READING
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